An Introduction to USANA Incelligence Technology®

USANA InCelligence Technology® is intelligent supplement design. It’s a nutritional technology—not a single product or a product line. InCelligence is a platform for creating products that support optimal cellular health through a natural process called cell signaling.*

This technology utilizes molecular targeting of nutrients to optimize cellular function. Key nutrients, scientifically proven to be effective cell-signaling molecules, speak your cell’s language.*

They cut through the biochemical noise—whether naturally occurring or from your lifestyle or environment—to activate your body’s abilities to support vibrant health.*

The Four Types of Nutrients and Cellular Interaction

Your diet is so much more than the calorie count. The food you eat contains a variety of nutrients. We put them in four basic categories:

  1. Essential Micro- and Macronutrients: Macronutrients are the big things (hence the macro)—protein, carbohydrates, and fats. Your body uses them for calories (energy), and as building material for cells. Micronutrients are found in the fruits and vegetables we eat. That’s where a lot of our vitamins and minerals come from.
  2. Antioxidant Protection: Just the act of living, breathing, and going through your day creates damaging oxidants. That’s why you need antioxidants. Living without enough of these important nutrients can cause problems and compromise health over time. In the broadest sense, an antioxidant is any oxidant scavenger. Dietary antioxidants include vitamins and other organic compounds that neutralize oxidants at a one-for-one or one-for-two ratio. So each molecule of an antioxidant like vitamin C can take care of one or two oxidants.
  1. Additional Nutritional Support: These additional nutrients fall outside the category of essential vitamins and minerals. So you won’t encounter a nutritional deficiency disease without them. But they have been found to provide additional health benefits. Nutrients like lutein, zeaxanthin, and glucosamine are deposited in specific areas of the body to provide a targeted benefit—like supporting healthy vision, cognitive function, skin health, and joint health.
  2. USANA InCelligence Technology: We’ve known for centuries that fruits and vegetables are good for us, but scientists had to find out why. They pulled out all the big things, like vitamins, and kept digging deeper. The search led them to phytonutrients—other compounds plants make, like the ones that give them bright colors. After all, if you think about it, the best chemists in the world are plants.

In high concentrations in test tubes, the compounds were great antioxidants. But they couldn’t figure out exactly how they were still working at the lower concentrations they could achieve in the human body. Something else had to be happening.

It was cell signaling. This relatively new understanding of phytonutrients’ abilities is the basis for InCelligence technology. USANA scientists isolate key nutrients—like resveratrol and quercetin—that work on cell-signaling pathways to illicit health benefits inside your cells.*

Cell Signaling Basics

Your cells are intelligent. They can sense and respond to their internal and external environments through cell signaling. So at a very basic level, this process is nothing more than a cell responding to internal or external molecules.

Receptor molecules in the cells sense their internal and external environment. These interactions trigger a chain reaction (think of a line of dominoes) that can turn on genes and activate a variety of cellular responses.

There can also be signal amplification. So very small amounts of the right nutrients targeted to the right cellular landing spots can have big impacts.

If you’re ready to dig deeper into cell-signaling, we have an in-depth description for you.

Supporting Cellular Communication Pathways

Age, lifestyle, and environmental factors can make it harder for your cells to communicate effectively. InCelligence supports your cellular communication pathways, helping maintain their health and yours.

We have the ability to target specific pathways with nutrients. Supporting the free flow of cellular information allows a broad spectrum of pathways to be positively impacted. Here’s just a few examples of what supporting and turning on these cell-signaling pathways can do:

  • Optimize cellular function.*
  • Support a healthy immune system.*
  • Support the body’s natural detoxification processes.*
  • Optimize the production of powerful antioxidants made inside cells.*
  • Support cellular clean-up processes.*

Cellular Strength Training for Resilience and Adaptability

Exercise strengthens your body, making it more resilient and adaptable. Your cells need the same thing. That’s why InCelligence is like strength training for your cells.

Hormesis is the scientific term you could use to describe this kind of cellular exercise. You stress cells to increase their resilience and adaptability—just like exercise stresses your body to ultimately make it stronger. The nutrients used in InCelligence complexes evolved as plants’ protection from the sun and hungry animals. So even though you’re getting a safe dose of these “cellular stressors” your cells still trigger protective responses.*

Flexing those cellular muscles helps create resilient cells that can more easily adapt to your lifestyle. Taking the proactive approach of turning on these natural processes also optimizes the natural longevity of cellular function.*

Products Made with USANA InCellience Technology

USANA utilizes InCelligence cell-signaling technology to formulate a variety of products that provide different benefits.

USANA® CellSentials™: Contains Vita-Antioxidant™  and Core Minerals™. CellSentials supplies carefully balanced levels of high-quality vitamins and antioxidants and a balanced range of highly absorbable essential minerals and trace minerals. It’s designed to provide an essential foundation of nourishment and powerful antioxidant protection. The InCelligence Complex also uses nutrients to unlock natural processes that support the health of your cells.*

HealthPak™: Convenient AM and PM packets containing Vita-Antioxidant, Core Minerals, CellSentials Booster, and USANA® MagneCal D™ —a bone-health supplement that was not formulated with USANA InCelligence Technology. All the core supplements you need in one product for full support of your healthy lifestyle.*

Proglucamune™: Daily immune-support supplement with zinc and the InCelligence Beta-Glucan Complex. It supports the body’s ability to adapt and respond to the effects occasional, everyday stress or strenuous exercise can have on immune function. InCelligence Beta-Glucan Complex uses baker’s yeast and a combination of mushrooms to prime immune cells’ natural protective responses so they can effectively protect health.*

Hepasil DTX™: Comprehensive liver-support formula featuring the InCelligence Detox-Support Complex. The complex delivers a comprehensive array of phytonutrients, including green-tea extract, milk-thistle extract, broccoli concentrate, turmeric, and USANA’s patented Olivol® olive-fruit extract. This helps to activate your liver cells’ natural protective antioxidant and detoxification processes.*

Procosa®: Supports joint function and comfort. It also helps regulate normal cartilage formation that helps cushion your joints. The InCelligence Joint-Support Complex in Procosa helps trigger a process in cartilage cells that helps renew healthy joint-cell function and support healthy joint aging. The complex also influences signaling pathways that modulate your body’s natural responses to the temporary, normal inflammation resulting from exercise. This helps proactively promote a healthy immune and inflammatory response after exercise.*

USANA Unveils New, Comprehensive Bone-Health Supplement

SALT LAKE CITY, March 27, 2017 /PRNewswire/ -- USANA (NYSE: USNA) remains at the forefront of health and nutrition, creating supplements to improve the health and wellness of its customers. Its newest product — MagneCal D™ — is an all-encompassing bone-health supplement that combines optimal amounts of magnesium, calcium and vitamin D to help individuals maintain a strong, healthy body.*

"We found people were consuming plenty of calcium, but were getting less than the recommended amounts of magnesium and vitamin D. This gave us the unique opportunity to formulate a supplement to help balance out the body's levels," says USANA's chief scientific officer, Dr. Robert Sinnott. "Through the direction of USANA's founder Dr. Myron Wentz, we calculated the perfect ratio of calcium to magnesium that you'll find in the new MagneCal D supplement."

USANA's MagneCal D supplement contains a healthy 1:1 ratio of magnesium and calcium as well as advanced levels of vitamin D. MagneCal D helps restore a better balance of these nutrients in the body and supports your health better than products with low to no magnesium or vitamin D.* MagneCal D was designed to work seamlessly as a core optimizer for USANA's flagship triple-action cellular nutrition system — CellSentials™.

"We typically do not get enough magnesium in our diets alone, which creates an unbalanced ratio of calcium to magnesium in our bodies," says USANA's executive director of global research and development, Dr. John Cuomo. "We're excited to give consumers a healthy combination of calcium, magnesium and vitamin D to not only maintain strong, healthy bones and teeth, but also support cardiovascular and metabolic health."*

For more information about USANA and its new MagneCal D product, go to

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 

USANA Ranked No. 1 Choice for Consumers

SALT LAKE CITY, Feb. 27, 2017 /PRNewswire/ -- Global health and wellness company USANA continues to receive public acclaim as they were recently named the 2017 Top Rated Direct Selling Brand in's Survey of Vitamin and Supplement Users. The award was presented to USANA based on customer satisfaction, with a greater percentage of consumers being "highly satisfied" with USANA than with other direct selling brands. For more about's customer survey, visit:  

Find out for yourself why USANA ranks as the top choice for consumers. Go to and shop for a wide variety of high-quality nutritionals, healthy food and personal care products.

"Receiving this kind of feedback directly from our consumers is something we value a great deal. It serves as an indicator of our passion and focus for putting our customers first," says Dan Macuga, USANA's chief communications officer. "We are proud to be regarded once again as the top brand in the very competitive direct selling industry. Our dedication to providing world class products and customer service is reflected in our customer loyalty and the feedback they provide us." is an independent, third-party supplement testing company providing results, reviews, ratings and comparisons of vitamins, supplements, herbs and nutrition products to consumers.

"This top rating demonstrates high satisfaction among USANA supplement users," said President Dr. Tod Cooperman.

USANA has now been rated as the No. 1 direct selling brand by for the fourth time.

The Evolution of Why

Dear USANA Friends -

Many times over the past 25 years I’ve been asked to help individuals clarify their “WHY” — their personal compelling reason for building a USANA business. The requests are often similar to this e-mail I recently received. Here is just a part of the letter:

“Collette, I hope you can take a moment to point me in the right direction. I’ve read articles on the many reasons it is crucial to have a WHY.  However, when I try to pin it down I don’t seem to be able to put my finger on it. It’s very disconcerting.”

So here is a portion of the letter I sent back, sharing it with the hope that it will resonate with some of you:

Dear _______,

I can relate to the emotions you're expressing because there have been times over my years in USANA when I've questioned my efforts and my direction. As a woman who prides herself on saying, "YES!" it's easy to get distracted and sidetracked. When we're climbing any ladder, we need to periodically check our motives to make certain that ladder is leaning against the right building...a truth I learned many years ago from Stephen Covey.   

I believe our ultimate why changes and evolves with the seasons in our lives. Can you identify the reasons behind the blocks you're experiencing? Maybe your ultimate why in USANA is to become as healthy as you can possibly be. It might not have anything to do with rank advancements or the size of your check. Your "why" could be as simple as being an example for others to follow. Or possibly your “why” will be related to leaving a legacy for your children and grandchildren. Your “why” might be directly tied to future time freedom - the ability to retire on your own terms. I don't know your financial situation, but I've seen many people struggle to find a "why" because they're already financially comfortable.  In those cases, I’ve found the following questions helpful:

What would make you excited to jump out of bed in the morning?

What would you attempt if you knew you could not fail?

What if you were suddenly struck by lightning and became a genius?  What would you want to accomplish?

Is there something you've always wanted to learn...perhaps a new language, a new talent or skill?

On the other hand, if finances are holding you back, here are some questions that might get the juices flowing:

If you suddenly inherited ten million dollars, what would you do TODAY?

What is one place you've always wanted to visit?

If you knew you were going to pass to the other side next week, is there a memory you'd want to make before that time came?

I hope you're getting the idea.  Pinpointing your “why” is about asking yourself questions (lots of them), pondering those questions, making some decisions and then taking baby steps in that direction.  Then, along the way we can make numerous course corrections as we receive personal insights.

I’ve actually adjusted my “why” many times over the past quarter century and through this process of looking inward I’ve gained clarity and understanding about what really matters to me.  

Thank you for writing and as always, light and love as you travel this journey.



Omega-3 Fatty Acids Support Heart Health

Order USANA's award-winning Omega-3 supplement.

Heart disease is a leading cause of death for both men and women. There are many risk factors that can contribute to developing heart disease. Some risk factors cannot be modified like age and family history. But others such as smoking, poor diet, lack of exercise, eating fruits and vegetables, and high blood pressure are all modifiable by making healthier lifestyle choices.

Research presented at the 2016 American Heart Association’s Scientific Sessions showed a positive correlation between circulating omega-3 fatty acids and a major risk factor for heart disease. In this study, 2036 young healthy adults volunteered. Researchers measured blood pressure and blood levels of omega-3 fatty acids. Individuals were then divided into four groups, from those with the highest amount of omega-3 fatty acids in their blood to those with the lowest levels. The results showed that healthy young adults who had the highest blood levels of omega-3 fatty acids had lower systolic and diastolic blood pressures than healthy young adults with the lowest levels.

These important healthy fats are found mostly in fish and some plant sources. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are largely found in fish, especially cold water fish like salmon, tuna, mackerel and sardines (sometimes called “marine omega-3’s”). Vegetarian sources include some vegetable oils, walnuts, and flax seeds. However, the primary omega-3 fatty acid found in plant sources is alpha-linolenic acid (ALA). Conversion of ALA to EPA and DHA is limited in humans and generally used for energy.

This is not the first study to associate higher levels of omega-3 fatty acids with a decreased risk of cardiovascular disease but adds further evidence that promoting diets rich in omega-3 fatty acids can help support heart health.

American Heart Association’s Scientific Sessions 2016.

Clark CM, Monahan KD, Drew RC. Omega-3 polyunsaturated fatty acid supplementation attenuates blood pressure increase at onset of isometric handgrip exercise in healthy young and older humans. Physiol Rep. 2016;4(14).

Walser B, Giordano RM, Stebbins CL. Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction. Eur J Appl Physiol. 2006;97(3):347-54.

Multivitamin Use Before Pregnancy Is Associated With a Lower Risk of Preterm Birth

Newly pregnant women are often in a hurry to start taking prenatal supplements as soon as they discover they are pregnant. While they certainly should, it is often too late to provide some of the important preventive benefits of multivitamins which are crucial BEFORE conception.

In the opinion of many experts, all women of childbearing age should be taking a good multivitamin in addition to following a healthy diet. While multivitamins will not completely ensure a premature birth won’t happen, why not take care of your health (and your baby’s) and lessen the risk?

A study published in the American Journal of Epidemiology found that the use of multivitamin supplements by women prior to becoming pregnant was associated with fewer preterm deliveries. Preterm birth is defined as birth at less than 37 weeks of gestation and is associated with a lower rate of infant survival during the first year of life.

Researchers utilized data from the Pregnancy, Infection and Nutrition Study which recruited 2,010 women during weeks 24 through 29 of pregnancy. They compared the incidence of preterm delivery among women who took multivitamins prior to conception, before conception and during pregnancy, during pregnancy only, or not at all.

Women who took a multivitamin supplement before conception had half the risk of early and late preterm delivery than those who took no vitamins. Women who used multivitamins only during pregnancy had approximately the same amount of preterm births when compared to women who took none at all.

This study, as well as many previous studies, reinforces the concern that waiting until pregnancy is confirmed may be too late for nutritional intervention to benefit many pregnancy outcomes.

Vahratian A, Siega-riz AM, Savitz DA, Thorp JM. Multivitamin use and the risk of preterm birth. Am J Epidemiol. 2004;160(9):886-92.

Omega-3 Supplementation Improves Neurodevelopment in Children

Purchase top quality Omega-3 in USANA's BiOmega

A new systematic review and meta-analysis by Harvard and Tufts researchers included 15 trials and over 2,500 children. Both maternal and child supplementation of EPA/DHA improved neurodevelopment.

Study Conclusion:
"Omega-3 supplementation during either pregnancy or infancy improves child neurodevelopment. These findings indicate the importance of sufficient polyunsaturated fatty acid intake by pregnant women and young children."…/1_Supplement/295.5.abstract…

Vitamin E Intake May Be Linked to Increased Bone Density and Reduced Fracture Risk

Purchase our CellSentials containing the highest quality Vitamin E

Recent studies have indicated that oxidative stress may be a contributing factor in the development of decreased bone density and an increased risk of bone fracture.

The study, published in the journal Osteoporosis International, included 21,774 Norwegian men and women aged 65-79 that were part of a community-based health study. Serum Vitamin E concentrations were measured at the beginning of the study and subjects were followed for 11 years.

During the course of the follow up, 1,168 hip fractures were reported in both men and women. After adjusting for smoking, month of blood sample, BMI, education, physical inactivity, self-rated health, and serum 25-hydroxy vitamin D (25(OH)D), serum vitamin E levels showed a linear inverse association with hip fracture risk. Among subjects in the lowest quartile (25%) of serum Vitamin E, the risk of hip fracture was 51% higher than those whose levels were among the top 25%.

In this population, low serum vitamin E concentrations were associated with an increased risk of hip fractures. These results confirm the findings of two recent cohort studies, which also found an increased risk of bone fracture among older adults with low serum vitamin E concentrations. The researchers suggest that in addition to its antioxidant effect, vitamin E could have a direct role in bone remodeling. However, further research is needed to clarify the role of vitamin E in maintaining bone health.

Holvik K, Gjesdal CG, Tell GS, et al. Low serum concentrations of alpha-tocopherol are associated with increased risk of hip fracture. A NOREPOS study. Osteoporos Int. 2014;25(11):2545-54.

Michaëlsson K, Wolk A, Byberg L, Ärnlöv J, Melhus H. Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies. Am J Clin Nutr. 2014;99(1):107-14.